27468-20-8
Chemical Structure
Deoxyneocryptotanshinone
- CAS No.: 27468-20-8
- Formula:C19H22O3
- Molecular Weight:298.38
IUPAC Name: 3-hydroxy-2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione
InChIKey: BIDSIGUBHQOWEC-UHFFFAOYSA-N
SMILES: O=C1C(C(C)C)=C(O)C(C2=C1C=CC3=C2CCCC3(C)C)=O
Biological Activity: Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].
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Deoxyneocryptotanshinone | Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research. | |||||||||||||||||||||
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- [1]. Ting Yu, et al. Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations. Comput Biol Chem. 2018 Jun;74:273-285. [Content Brief]
- [2]. Da Hye Kim, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73. [Content Brief]
Keywords
