2756557-83-0
Chemical Structure
α5β1 integrin agonist-1
- CAS No.: 2756557-83-0
- Formula:C24H26FN5O9
- Molecular Weight:547.49
IUPAC Name: 2-((2R,3S)-3-((R)-1-((3-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)propanoyl)oxy)ethyl)-4-oxo-1-(o-tolylcarbamoyl)azetidin-2-yl)acetic acid
InChIKey: VYBDMSHMVUFIRG-OWDMVUQNSA-N
SMILES: OC(C[C@H]1N(C([C@]1([H])[C@@H](C)OC(CCNC(CN2C(NC(C(F)=C2)=O)=O)=O)=O)=O)C(NC3=C(C=CC=C3)C)=O)=O
Biological Activity: α5β1 integrin agonist-1 is an α5β1 integrin agonist, with an EC50 of 1.5 nM. α5β1 integrin agonist-1 inhabits α4β1 integrin (IC50 = 2.99 μM) in Jurkat/VCAM-1 adhesion assayα5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the caspase 3/7 pathway in α5β1 integrin-expressing K562 cancer cells. α5β1 integrin agonist-1 can be used for the study of cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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α5β1 integrin agonist-1 | 99.67% | α5β1 integrin agonist-1 is an α5β1 integrin agonist, with an EC50 of 1.5 nM. α5β1 integrin agonist-1 inhabits α4β1 integrin (IC50 = 2.99 μM) in Jurkat/VCAM-1 adhesion assayα5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the caspase 3/7 pathway in α5β1 integrin-expressing K562 cancer cells. α5β1 integrin agonist-1 can be used for the study of cancer. | ||||||||||||||||||||
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Keywords
