2763260-39-3
Chemical Structure
NRX-252114
- CAS No.: 2763260-39-3
- Formula:C22H12Cl2F3N3O2S
- Molecular Weight:510.32
IUPAC Name: 2-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl)isoindoline-4-carbonitrile
InChIKey: BMQXGPBUQGPLOV-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC2=C1CN(C(C3=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)NC3=O)=O)C2
Biological Activity: NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NRX-252114 | 99.43% | NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation. | ||||||||||||||||||||
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Keywords
