27652-34-2
Chemical Structure
Thio-ITP
Synonym(s): 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5'-triphosphate; 6-Thio-ITP
- CAS No.: 27652-34-2
- Formula:C10H15N4O13P3S
- Molecular Weight:524.23
IUPAC Name: ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-mercapto-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: GQNRDWAOABGWGP-KQYNXXCUSA-N
SMILES: SC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3
Biological Activity: Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].
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Thio-ITP | Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM). | |||||||||||||||||||||
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