2799-07-7
2799-07-7
Chemical Structure
S-Trityl-L-cysteine
Synonym(s): NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine
- CAS No.: 2799-07-7
- Formula:C22H21NO2S
- Molecular Weight:363.47
IUPAC Name: S-trityl-L-cysteine
InChIKey: DLMYFMLKORXJPO-FQEVSTJZSA-N
SMILES: N[C@@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(O)=O
Biological Activity: S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2].
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S-Trityl-L-cysteine | 99.53% | S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities. | ||||||||||||||||||||
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S-Trityl-L-cysteine (Standard) | ≥98% | S-Trityl-L-cysteine (Standard) is the analytical standard of S-Trityl-L-cysteine (HY-W011102). This product is intended for research and analytical applications. S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric Kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-W053550H-D-Cys(Trt)-OH -
Similarity Score 0.85
HY-W011156Mpa(Trt) -
Similarity Score 0.83
![N-[S-Trityl-L-cysteinyl]glycine Chemical Structure](//file.medchemexpress.com/product_pic/hy-w108635.gif)
HY-W108635N-[S-Trityl-L-cysteinyl]glycine -
Similarity Score 0.80
HY-4028533-(Tritylthio)propylamine -
Similarity Score 0.79
HY-W1438226-(Tritylthio)hexanoic acid -
Similarity Score 0.76
HY-W008178(R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid -
Similarity Score 0.76
HY-W010835Boc-D-Cys(Trt)-OH -
Similarity Score 0.76
HY-151674N3-L-Cys(Trt)-OH (CHA) -
Similarity Score 0.74
HY-W1143950O-Trityl-L-serine -
Explore the MedChemAI to find more analogs
![N-[S-Trityl-L-cysteinyl]glycine Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w108635.gif)
References
- [1]. Wei Wu, et al. S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma. Oncol Lett. 2018 Jul;16(1):1023-1030. [Content Brief]
- [2]. Salvatore DeBonis, et al. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther. 2004 Sep;3(9):1079-90. [Content Brief]
