2810880-82-9
2810880-82-9
Chemical Structure
HPK1-IN-46
- CAS No.: 2810880-82-9
- Formula:C25H25FN6O
- Molecular Weight:444.50
InChIKey: CDEQFDSQRKTMBV-UHFFFAOYSA-N
SMILES: FC1=CC=CC(OC)=C1C2=CC3=C(C=NN3C4=CC=CC(N5CC6N(C(CC6)C5)C)=N4)C=N2
Biological Activity: HPK1-IN-46 (Compound 36) is an efficient and highly selective HPK1 reverse indazole inhibitor with an IC50 value of 1.1 nM. HPK1-IN-46 exhibits high selectivity for CDK2, JAK1, and JAK2. HPK1-IN-46 inhibits SLP76 phosphorylation mediated by HPK1, reverses T-cell inhibition, and enhances anti-tumor immunity. HPK1-IN-46 can be used in immunotherapy research for tumors[1].
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HPK1-IN-46 | HPK1-IN-46 (Compound 36) is an efficient and highly selective HPK1 reverse indazole inhibitor with an IC50 value of 1.1 nM. HPK1-IN-46 exhibits high selectivity for CDK2, JAK1, and JAK2. HPK1-IN-46 inhibits SLP76 phosphorylation mediated by HPK1, reverses T-cell inhibition, and enhances anti-tumor immunity. HPK1-IN-46 can be used in immunotherapy research for tumors. | |||||||||||||||||||||
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