2849348-38-3
Chemical Structure
hCAIX-IN-16
- CAS No.: 2849348-38-3
- Formula:C20H20N8O2S
- Molecular Weight:436.49
IUPAC Name: (E)-4-((4-amino-6-(1-cyano-2-(4-(dimethylamino)phenyl)vinyl)-1,3,5-triazin-2-yl)amino)benzenesulfonamide
InChIKey: MJQFSCQHAOTUNM-SDNWHVSQSA-N
SMILES: O=S(C1=CC=C(NC2=NC(N)=NC(/C(C#N)=C/C3=CC=C(N(C)C)C=C3)=N2)C=C1)(N)=O
Biological Activity: hCAIX-IN-16 (Compound 12d) is hCA IX inhibitor, with Ki values of 190.0 and 187.9 nM for hCA IX and hCA XII, respectively. hCAIX-IN-16 can arrest the cell cycle of breast cancer MDA-MB-468 in G0-G1 and S phase and induce apoptosis. hCAIX-IN-16 shows good broad-spectrum anticancer activity and can be used for cancer research[1].
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hCAIX-IN-16 | hCAIX-IN-16 (Compound 12d) is hCA IX inhibitor, with Ki values of 190.0 and 187.9 nM for hCA IX and hCA XII, respectively. hCAIX-IN-16 can arrest the cell cycle of breast cancer MDA-MB-468 in G0-G1 and S phase and induce apoptosis. hCAIX-IN-16 shows good broad-spectrum anticancer activity and can be used for cancer research. | |||||||||||||||||||||
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