2882845-50-1
Chemical Structure
PROTAC EGFR degrader 4
- CAS. Nr.: 2882845-50-1
- Formula:C55H70N12O4S
- Molecular Weight:995.29
IUPAC Name: 4-(6-chloro-3-nitro-2-((phenylsulfonyl)methyl)imidazo[1,2-a]pyridin-8-yl)but-3-yn-1-ol
InChIKey: MCPFQJKJCFMAIH-CRHSMECVSA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7N=C(N(C7=N6)C8CCCC8)NC9=CC=CC=C9)=O)=O)O)=O
Biological Activity: PROTAC EGFR degrader 4 is an EGFRdel19 and EGFRL858R/T790M degrader with anti-proliferative activity. PROTAC EGFR degrader 4 induces degradation of mutant EGFR variants via ubiquitination and autophagy. PROTAC EGFR degrader 4 suppresses EGFR pathway signal transduction. PROTAC EGFR degrader 4 induces apoptosis, arrests cell cycle, and suppresses cell colony formation in cancer cells. PROTAC EGFR degrader 4 can be used for the research of non-small cell lung cancer[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC EGFR degrader 4 | 99.70% | PROTAC EGFR degrader 4 is an EGFRdel19 and EGFRL858R/T790M degrader with anti-proliferative activity. PROTAC EGFR degrader 4 induces degradation of mutant EGFR variants via ubiquitination and autophagy. PROTAC EGFR degrader 4 suppresses EGFR pathway signal transduction. PROTAC EGFR degrader 4 induces apoptosis, arrests cell cycle, and suppresses cell colony formation in cancer cells. PROTAC EGFR degrader 4 can be used for the research of non-small cell lung cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.84
HY-144605PROTAC EGFR degrader 3 -
Similarity Score 0.70
HY-146422PROTAC EGFR degrader 5 -
Similarity Score 0.68
HY-129180XY028-133 -
Similarity Score 0.67
HY-148062RSS0680 -
Similarity Score 0.67
HY-181231PROTAC CDK9 degrader-12 -
Similarity Score 0.64
HY-149616PPM-3 -
Similarity Score 0.63
HY-179424PROTAC HIF-1α degrader-2 -
Similarity Score 0.63
HY-148065FMF-06-098-1 -
Similarity Score 0.62
HY-146022SIAIS117 -
Explore the MedChemAI to find more analogs
