2882845-50-1
Chemical Structure
PROTAC EGFR degrader 4
- CAS No.: 2882845-50-1
- Formula:C55H70N12O4S
- Molecular Weight:995.29
IUPAC Name: 4-(6-chloro-3-nitro-2-((phenylsulfonyl)methyl)imidazo[1,2-a]pyridin-8-yl)but-3-yn-1-ol
InChIKey: MCPFQJKJCFMAIH-CRHSMECVSA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7N=C(N(C7=N6)C8CCCC8)NC9=CC=CC=C9)=O)=O)O)=O
Biological Activity: PROTAC EGFR degrader 4 is an EGFRdel19 and EGFRL858R/T790M degrader with anti-proliferative activity. PROTAC EGFR degrader 4 induces degradation of mutant EGFR variants via ubiquitination and autophagy. PROTAC EGFR degrader 4 suppresses EGFR pathway signal transduction. PROTAC EGFR degrader 4 induces apoptosis, arrests cell cycle, and suppresses cell colony formation in cancer cells. PROTAC EGFR degrader 4 can be used for the research of non-small cell lung cancer[1].
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PROTAC EGFR degrader 4 | 99.70% | PROTAC EGFR degrader 4 is an EGFRdel19 and EGFRL858R/T790M degrader with anti-proliferative activity. PROTAC EGFR degrader 4 induces degradation of mutant EGFR variants via ubiquitination and autophagy. PROTAC EGFR degrader 4 suppresses EGFR pathway signal transduction. PROTAC EGFR degrader 4 induces apoptosis, arrests cell cycle, and suppresses cell colony formation in cancer cells. PROTAC EGFR degrader 4 can be used for the research of non-small cell lung cancer. | ||||||||||||||||||||
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Keywords
