2909443-06-5
2909443-06-5
Chemical Structure
MsbA-IN-5
- CAS No.: 2909443-06-5
- Formula:C23H19Cl2N5O
- Molecular Weight:452.34
IUPAC Name: (S,E)-3-(2-(2H-tetrazol-5-yl)vinyl)-4-cyclopropyl-6-(1-(2,6-dichlorophenyl)ethoxy)quinoline
InChIKey: MKYKJTCWOHWXDW-RSPDNQDQSA-N
SMILES: C[C@@H](C1=C(Cl)C=CC=C1Cl)OC2=CC=C3N=CC(/C=C/C4=NNN=N4)=C(C5CC5)C3=C2
Biological Activity: MsbA-IN-5 (compound 40) is a potent and highly selective MsbA inhibitor with an IC50 value of 2 nM. MsbA-IN-5 has inhibitory activity against Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae with MICs of 12 μM, 12 μM and 25 μM, respectively. MsbA-IN-5 can be used for researching anti-Gram-negative bacteria[1].
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MsbA-IN-5 | MsbA-IN-5 (compound 40) is a potent and highly selective MsbA inhibitor with an IC50 value of 2 nM. MsbA-IN-5 has inhibitory activity against Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae with MICs of 12 μM, 12 μM and 25 μM, respectively. MsbA-IN-5 can be used for researching anti-Gram-negative bacteria. | |||||||||||||||||||||
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