29176-29-2
29176-29-2
Chemical Structure
Lofendazam
- CAS No.: 29176-29-2
- Formula:C15H13ClN2O
- Molecular Weight:272.73
IUPAC Name: 8-chloro-1-phenyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
InChIKey: IUJQOUHDFKALCY-UHFFFAOYSA-N
SMILES: O=C1N(C=2C=CC=CC2)C3=CC(Cl)=CC=C3NCC1
Biological Activity: Lofendazam is a major metabolite of Arfendazam. Lofendazam acts as a positive allosteric modulator/partial agonist of GABAa receptor, with IC50 values of 10.1 nM and 9.1 nM in bovine cerebral cortex and bovine cerebellum, respectively; its in vivo ED50 via oral administration is 233 µmol/kg[1].
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Lofendazam | Lofendazam is a major metabolite of Arfendazam. Lofendazam acts as a positive allosteric modulator/partial agonist of GABAa receptor, with IC50 values of 10.1 nM and 9.1 nM in bovine cerebral cortex and bovine cerebellum, respectively; its in vivo ED50 via oral administration is 233 µmol/kg. | |||||||||||||||||||||
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References
Keywords
