2933758-40-6
2933758-40-6
Chemical Structure
Oxaprozin-d5
Synonym(s): Oxaprozinum-d5;Wy21743-d5
- CAS No.: 2933758-40-6
- Formula:C18H10D5NO3
- Molecular Weight:298.35
IUPAC Name: 3-(4-phenyl-5-(phenyl-d5)oxazol-2-yl)propanoic acid
InChIKey: OFPXSFXSNFPTHF-OUHXUHDZSA-N
SMILES: O=C(O)CCC1=NC(C2=CC=CC=C2)=C(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])O1
Biological Activity: Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Oxaprozin-d5 | Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. | |||||||||||||||||||||
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Oxaprozin (Standard) | ≥98% | Oxaprozin (Standard) is the analytical standard of Oxaprozin. This product is intended for research and analytical applications. Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties. | ||||||||||||||||||||
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Oxaprozin-d10 | Oxaprozin-d10 (Oxaprozinum-d10; Wy21743-d10) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties. | |||||||||||||||||||||
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Oxaprozin-d4 | 99.08% | Oxaprozin-d4 is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID). | ||||||||||||||||||||
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Oxaprozin | 99.94% | Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties. | ||||||||||||||||||||
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