29491-75-6
29491-75-6
Chemical Structure
8MDP
- CAS No.: 29491-75-6
- Formula:C28H48N8O4
- Molecular Weight:560.73
IUPAC Name: 2,2',2'',2'''-((4,8-di(azocan-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetrakis(ethan-1-ol)
InChIKey: KXOCTHJHIGLQKJ-UHFFFAOYSA-N
SMILES: OCCN(CCO)C1=NC(N2CCCCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCCCC4)C3=N1
Biological Activity: 8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC50 of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H3] uridine by K562 cells and K15NTD cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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8MDP | 97.9% | 8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC50 of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H3] uridine by K562 cells and K15NTD cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-B0312Dipyridamole -
Similarity Score 0.74
HY-106618Mopidamol -
Similarity Score 0.69
HY-W740060Dipyridamole Mono-O-β-D-glucuronide -
Similarity Score 0.59
HY-B0312S1Dipyridamole-d16 -
Similarity Score 0.57
HY-119291RA642 -
Similarity Score 0.52
HY-B0312SDipyridamole-d20 -
Similarity Score 0.51
HY-110165hENT4-IN-1 -
Similarity Score 0.46
HY-159989UNC10142 -
Similarity Score 0.45
HY-12335AUNC0379 TFA -
Explore the MedChemAI to find more analogs
References
- [1]. Lin W, et al. Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe. Bioconjug Chem. 2011 Jun 15;22(6):1221-7. [Content Brief]
- [2]. Lin W, et al. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem. 2007 Aug 9;50(16):3906-20. [Content Brief]
