1. Epigenetics
  2. Histone Methyltransferase
  3. UNC0379 TFA

UNC0379 TFA 

Cat. No.: HY-12335A
Handling Instructions

UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases.

For research use only. We do not sell to patients.

UNC0379 TFA Chemical Structure

UNC0379 TFA Chemical Structure

CAS No. : 1620401-83-3

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Top Publications Citing Use of Products

    UNC0379 TFA purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129.

    The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.
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    Description

    UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases[1].

    IC50 & Target

    SETD8/KMT5A[1]

    Molecular Weight

    527.58

    Formula

    C₂₅H₃₆F₃N₅O₄

    CAS No.

    1620401-83-3

    SMILES

    COC1=C(OC)C=C2C(N=C(N3CCCC3)N=C2NCCCCCN4CCCC4)=C1.O=C(O)C(F)(F)F

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    References
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    UNC0379 TFA
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