2991817-99-1
2991817-99-1
Chemical Structure
MGD-4
- CAS No.: 2991817-99-1
- Formula:C14H16N4O3
- Molecular Weight:288.30
InChIKey: MXJNMZBXMSTPNN-UHFFFAOYSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)N(C)CC3=C(N)C=CC=C31
Biological Activity: MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].
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MGD-4 | MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma. | |||||||||||||||||||||
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References
Keywords
