3032075-26-3
Chemical Structure
IRAK4-IN-18
- CAS No.: 3032075-26-3
- Formula:C24H25FN6O3
- Molecular Weight:464.49
IUPAC Name: 15H-2-oxa-7-aza-1(7,5)-benzo[b]pyrido[4,3-e][1,4]oxazinacyclododecaphane
InChIKey: MPYUEFXHKFQGQP-PZCZFJQHSA-N
SMILES: O=C(N)[C@@H]1[C@@H]([C@@H]2C[C@H]1C=C2)NC3=NC(NC4=CC(N5CCOCC5)=CC(F)=C4)=NC6=C3OC=C6
Biological Activity: IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease[1].
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IRAK4-IN-18 | IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease. | |||||||||||||||||||||
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Keywords
