3036009-40-9
3036009-40-9
Chemical Structure
MerTK/Axl-IN-1
- CAS No.: 3036009-40-9
- Formula:C40H47FN6O4
- Molecular Weight:694.84
InChIKey: LYOFWWMIRHDSLV-AKQLPAHTSA-N
SMILES: FC1=NC=CC=C1C2=CC(C(N[C@H]3CCC[C@@H]3OCC4=CC=C(C5=CC(CCC[C@@H]6N7CCN(C[C@@H](CO)O)CC7)=C6C=C5)C=C4)=O)=C(N)N=C2
Biological Activity: MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual MerTK/Axl inhibitor, with IC50s of 4.2 and 8.8 nM in Ba/F3, and 0.2 and 0.9 nM in HTRF. MerTK/Axl-IN-1 results in pMerTK inhibition in vivo. MerTK/Axl-IN-1 has long half-life, high oral exposure and bioavailability[1].
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MerTK/Axl-IN-1 | MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual MerTK/Axl inhibitor, with IC50s of 4.2 and 8.8 nM in Ba/F3, and 0.2 and 0.9 nM in HTRF. MerTK/Axl-IN-1 results in pMerTK inhibition in vivo. MerTK/Axl-IN-1 has long half-life, high oral exposure and bioavailability. | |||||||||||||||||||||
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References
Keywords
