3036751-84-2
3036751-84-2
Chemical Structure
FGFR4-IN-19
- CAS No.: 3036751-84-2
- Formula:C21H14Cl3N5O4
- Molecular Weight:506.73
InChIKey: IRKXKBMGTVDZAJ-UHFFFAOYSA-N
SMILES: ClC(N=C1NC2=NC=C3C(C=CC(C4=C(C(OC)=CC(OC)=C4Cl)Cl)=C3)=N2)=CC=C1[N+]([O-])=O
Biological Activity: FGFR4-IN-19 (compound 8B) is a potent covalent fibroblast growth factor receptor 4 (FGFR4) inhibitor (IC50=1.2 nM). FGFR4-IN-19 achieves high efficiency and isotype selectivity by covalently targeting a rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 can be used for hepatocellular carcinoma (HCC) research[1].
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FGFR4-IN-19 | FGFR4-IN-19 (compound 8B) is a potent covalent fibroblast growth factor receptor 4 (FGFR4) inhibitor (IC50=1.2 nM). FGFR4-IN-19 achieves high efficiency and isotype selectivity by covalently targeting a rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 can be used for hepatocellular carcinoma (HCC) research. | |||||||||||||||||||||
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References
Keywords
