3038446-94-2
3038446-94-2
Chemical Structure
SK2188
Synonym(s): JB325
- CAS No.: 3038446-94-2
- Formula:C43H46ClFN6O10S
- Molecular Weight:893.38
InChIKey: YDRHAKKUUAJFHB-YCDNTZAYSA-N
SMILES: O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=C3C1=O
Biological Activity: SK2188 (JB325) is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SK2188 | 99.87% | SK2188 (JB325) is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma. | ||||||||||||||||||||
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References
Keywords
