304481-60-5
Chemical Structure
KM91104
- CAS No.: 304481-60-5
- Formula:C14H12N2O4
- Molecular Weight:272.26
IUPAC Name: (E)-3,4-dihydroxy-N'-(2-hydroxybenzylidene)benzohydrazide
InChIKey: GWVYHPUGEQGQSF-OVCLIPMQSA-N
SMILES: O=C(N/N=C/C1=CC=CC=C1O)C2=CC=C(O)C(O)=C2
Biological Activity: KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor (IC50 = 2.3 µM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV-TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein[1][2].
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KM91104 | 98.06% | KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor (IC50 = 2.3 µM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV-TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein. | ||||||||||||||||||||
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[1]. Giusi Marrone, et al. The AMPK-v-ATPase-pH axis: a key regulator of the pro-fibrogenic phenotype of
human hepatic stellate cells. - [2]. Göttle P, et al. Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Glia. 2019;67(1):160-170. [Content Brief]
Keywords
