3050611-33-8
3050611-33-8
Chemical Structure
PPARα/δ agonist 3
- CAS No.: 3050611-33-8
- Formula:C23H25F3N2O4
- Molecular Weight:450.45
InChIKey: SJFIYCLXFWXYJF-UHFFFAOYSA-N
SMILES: CC(C)(OC1=C(C)C=C(CN2CCN(C3=CC=C(C(F)(F)F)C=C3)C2=O)C=C1C)C(O)=O
Biological Activity: PPARα/δ agonist 3 (Compound 8) is the orally active agonist for PPAR, that activates PPARα, PPARδ and PPARγ with EC50s of 5.6, 3.4 and 1278 nM, respectively. PPARα/δ agonist 3 exhibits anticholestatic activity in mouse ANIT- or CDCA (HY-76847)-induced cholestatic liver disease models[1].
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PPARα/δ agonist 3 | PPARα/δ agonist 3 (Compound 8) is the orally active agonist for PPAR, that activates PPARα, PPARδ and PPARγ with EC50s of 5.6, 3.4 and 1278 nM, respectively. PPARα/δ agonist 3 exhibits anticholestatic activity in mouse ANIT- or CDCA (HY-76847)-induced cholestatic liver disease models. | |||||||||||||||||||||
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References
Keywords
