305372-78-5
305372-78-5
Chemical Structure
CCT036477
- CAS No.: 305372-78-5
- Formula:C21H18ClN3
- Molecular Weight:347.84
IUPAC Name: N-((4-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine
InChIKey: IFOHRIXRQPOHQZ-UHFFFAOYSA-N
SMILES: CC(NC1=C2C=CC=C1)=C2C(C3=CC=C(C=C3)Cl)NC4=NC=CC=C4
Biological Activity: CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CCT036477 | 99.42% | CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2). | ||||||||||||||||||||
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References
- [1]. Serttas R, et al. Pretreatment of prostate cancer cells with salinomycin and Wnt inhibitor increases the efficacy of cabazitaxel by inducing apoptosis and decreasing cancer stem cells. Med Oncol. 2023 Jun 1;40(7):194. [Content Brief]
- [2]. Mathur R, et al. Targeting Wnt pathway in mantle cell lymphoma-initiating cells. J Hematol Oncol. 2015 Jun 6;8:63. [Content Brief]
Keywords
