3058-01-3
3058-01-3
Chemical Structure
3-Methyladipic acid
- CAS No.: 3058-01-3
- Formula:C7H12O4
- Molecular Weight:160.17
IUPAC Name: 3-methylhexanedioic acid
InChIKey: SYEOWUNSTUDKGM-UHFFFAOYSA-N
SMILES: O=C(O)CC(C)CCC(O)=O
Biological Activity: 3-Methyladipic acid is the final metabolite produced by the degradation of phytanic acid via the ω-oxidation pathway when α-oxidation is impaired, and it is mainly excreted in urine. 3-Methyladipic acid is also present at low levels in healthy individuals, but is significantly elevated in Refsum disease, and can serve as a marker of ω-oxidation activity[1][2].
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3-Methyladipic acid | 98.0% | 3-Methyladipic acid is the final metabolite produced by the degradation of phytanic acid via the ω-oxidation pathway when α-oxidation is impaired, and it is mainly excreted in urine. 3-Methyladipic acid is also present at low levels in healthy individuals, but is significantly elevated in Refsum disease, and can serve as a marker of ω-oxidation activity. | ||||||||||||||||||||
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3-Methyladipic acid (Standard) | ≥98% | 3-Methyladipic acid (Standard) is the analytical standard of 3-Methyladipic acid (HY-113277). This product is intended for research and analytical applications. 3-Methyladipic acid is the final metabolite produced by the degradation of phytanic acid via the ω-oxidation pathway when α-oxidation is impaired, and it is mainly excreted in urine. 3-Methyladipic acid is also present at low levels in healthy individuals, but is significantly elevated in Refsum disease, and can serve as a marker of ω-oxidation activity. | ||||||||||||||||||||
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References
- [1]. Niwa T, et al. Pattern of aliphatic dicarboxylic acids in uremic serum including a new organic acid, 2,4-dimethyladipic acid. Clinica chimica acta; international journal of clinical chemistry. 1979 Nov 15;99(1):71-83.
- [2]. Wierzbicki AS, et al. Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation. Journal of neurochemistry. 2002 Mar;80(5):727-35. [Content Brief]
