3070532-72-5
Chemical Structure
HDAC3-IN-6
- CAS No.: 3070532-72-5
- Formula:C23H23N5O3
- Molecular Weight:417.46
InChIKey: NVEXGSNLIUWPBT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CNC(C2=CN=C(C3=CC=C4OC=CC4=C3)N2)=O)C=C1)NNCCC
Biological Activity: HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. HDAC3-IN-6 dose-dependently induces the expression of PD-L1. HDAC3-IN-6 induces more pronounced Apoptosis and production of ROS. HDAC3-IN-6 exhibits high antitumor efficacy against colorectal cancer[1].
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HDAC3-IN-6 | HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. HDAC3-IN-6 dose-dependently induces the expression of PD-L1. HDAC3-IN-6 induces more pronounced Apoptosis and production of ROS. HDAC3-IN-6 exhibits high antitumor efficacy against colorectal cancer. | |||||||||||||||||||||
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Keywords