3086791-85-4
Chemical Structure
DBCO-PEG4-GGFG-Triptolide
- CAS No.: 3086791-85-4
- Formula:C68H81N7O19
- Molecular Weight:1300.41
InChIKey: OGDDNNFXJPOYEJ-OJLWWQQFSA-N
SMILES: C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC(COCNC(CNC([C@H](CC8=CC=CC=C8)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N9CC%10=CC=CC=C%10C#CC%11=CC=CC=C%119)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: DBCO-PEG4-GGFG-Triptolide is a triptolide-based antibody-drug conjugate (ADC) payload, consisting of a DBCO click chemistry reactive group, a PEG4 linker, a cathepsin-cleavable GGFG peptide segment, and triptolide. DBCO-PEG4-GGFG-Triptolide binds to antibodies via glycosylation conjugation, releases active triptolide intracellularly to exert cytotoxic effects, and is commonly used in combination with camptothecin-class toxins (Exatecan (HY-13631) / DXd (HY-13631D)) for the preparation of dual-toxin ADCs[1].
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DBCO-PEG4-GGFG-Triptolide | DBCO-PEG4-GGFG-Triptolide is a triptolide-based antibody-drug conjugate (ADC) payload, consisting of a DBCO click chemistry reactive group, a PEG4 linker, a cathepsin-cleavable GGFG peptide segment, and triptolide. DBCO-PEG4-GGFG-Triptolide binds to antibodies via glycosylation conjugation, releases active triptolide intracellularly to exert cytotoxic effects, and is commonly used in combination with camptothecin-class toxins (Exatecan (HY-13631) / DXd (HY-13631D)) for the preparation of dual-toxin ADCs. | |||||||||||||||||||||
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