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Cat. No.: HY-188015

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DBCO-PEG4-GGFG-Triptolide

DBCO-PEG4-GGFG-Triptolide is a triptolide-based antibody-drug conjugate (ADC) payload, consisting of a DBCO click chemistry reactive group, a PEG4 linker, a cathepsin-cleavable GGFG peptide segment, and triptolide. DBCO-PEG4-GGFG-Triptolide binds to antibodies via glycosylation conjugation, releases active triptolide intracellularly to exert cytotoxic effects, and is commonly used in combination with camptothecin-class toxins (Exatecan (HY-13631) / DXd (HY-13631D)) for the preparation of dual-toxin ADCs.

For research use only. We do not sell to patients.

CAS No.: 3086791-85-4
Formula: C₆₈H₈₁N₇O₁₉
Molecular Weight:1300.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DBCO-PEG4-GGFG-Triptolide Chemical Structure

CAS No.: 3086791-85-4

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All ADC Payloads Isoforms :

In Vitro

ADC is a targeted biologic composed of a monoclonal antibody that targets a specific antigen, a cleavable or non-cleavable linker, and a highly active cytotoxic payload (small-molecule drug). It precisely delivers the payload into tumor cells via the antibody to achieve highly effective and low-toxicity killing effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3086791-85-4
Molecular Weight 1300.41
Formula C₆₈H₈₁N₇O₁₉
SMILES

C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC(COCNC(CNC([C@H](CC8=CC=CC=C8)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N9CC%10=CC=CC=C%10C#CC%11=CC=CC=C%119)=O)=O)=O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ke X, et al. Double-toxin antibody-drug conjugate and use thereof. International Patent Application No. WO 2025/103474 A1. Published May 22, 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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DBCO-PEG4-GGFG-Triptolide

All ADC Payloads Isoforms