325970-71-6
Chemical Structure
L67
Synonym(s): DNA Ligase Inhibitor
- CAS No.: 325970-71-6
- Formula:C16H14Br2N4O4
- Molecular Weight:486.11
IUPAC Name: (E)-2-((3,5-dibromo-4-methylphenyl)amino)-N'-(2-hydroxy-5-nitrobenzylidene)acetohydrazide
InChIKey: KFEPVFJQVOMODD-IFRROFPPSA-N
SMILES: BrC1=CC(NCC(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)=CC(Br)=C1C
Biological Activity: L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 μM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1-dependent apoptosis pathway in cancer cells, can be used in cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L67 | 98.0% | L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 μM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1-dependent apoptosis pathway in cancer cells, can be used in cancer research. | ||||||||||||||||||||
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References
- [1]. Sallmyr A, et al. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells. Cancer Res. 2016 Sep 15;76(18):5431-41. [Content Brief]
- [2]. Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. [Content Brief]
