33237-37-5
Chemical Structure
Rutaevin
- CAS No.: 33237-37-5
- Formula:C26H30O9
- Molecular Weight:486.51
IUPAC Name: (4aS,6aS,8R,8aS,8bR,9aS,12S,12aS,14aR,14bR)-12-(furan-3-yl)-8-hydroxy-6,6,8a,12a-tetramethyldecahydro-1H,3H-oxireno[2,3-d]pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-3,7,10(8H,9aH)-trione
InChIKey: YZMKFMIZNSOPSN-ZIQVUAKTSA-N
SMILES: C[C@]1([C@H]2O)[C@@]3([C@@H]4O3)[C@]([C@H](C5=COC=C5)OC4=O)(CC[C@]1([H])[C@]67[C@](C(C)(C)O[C@@]6([H])CC(OC7)=O)([H])C2=O)C
Biological Activity: Rutaevin is an antifungal toxin and CYP3A4 inactivator. Rutaevin requires NADPH-dependent bioactivation to generate cis-but-2-ene-1,4-dial, which then covalently modifies and mechanism-based inactivates human CYP3A4 (IC50=4.48 μM, Ki=15.98 μM), and interacts with substances such as glutathione. Rutaevin disrupts the cellular structure of Sirococcus conigenus, accumulates linearly in resistant larch after pathogen exposure, and induces liver toxicity in mice via oral administration. Rutaevin can be applied to research in fields related to larch shoot blight and other associated areas[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rutaevin | 99.77% | Rutaevin is an antifungal toxin and CYP3A4 inactivator. Rutaevin requires NADPH-dependent bioactivation to generate cis-but-2-ene-1,4-dial, which then covalently modifies and mechanism-based inactivates human CYP3A4 (IC50=4.48 μM, Ki=15.98 μM), and interacts with substances such as glutathione. Rutaevin disrupts the cellular structure of Sirococcus conigenus, accumulates linearly in resistant larch after pathogen exposure, and induces liver toxicity in mice via oral administration. Rutaevin can be applied to research in fields related to larch shoot blight and other associated areas. | ||||||||||||||||||||
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- [1]. Liu Y, et al. Cytochrome P450 mediated bioactivation of rutaevin, a bioactive and potentially hepatotoxic component of Evodia rutaecarpa[J]. Chemical Research in Toxicology, 2020, 33(12): 3054-3064.
- [2]. Zhang R, et al. From Resistance Mechanism to Green Application: Discovery of Rutaevin as a Key Phytoalexin in Larch and Cross-Species Resource Optimization. Plants (Basel). 2025;14(19):2947. Published 2025 Sep 23. [Content Brief]
Keywords
