34348-59-9
Chemical Structure
Isoegomaketone
- CAS No.: 34348-59-9
- Formula:C10H12O2
- Molecular Weight:164.20
IUPAC Name: (5-phenyl-4H-1,2,4-triazol-3-yl)methanamine hydrochloride
InChIKey: XEYCZVQIOJGCNL-ONEGZZNKSA-N
SMILES: CC(C)/C=C/C(C1=COC=C1)=O
Biological Activity: Isoegomaketone is an orally active apoptosis inducer and radiosensitizer. Isoegomaketone regulates multiple key signaling pathways such as PI3K/AKT/mTOR, NF-κB, MAPK, cleaves Caspase family proteins and PARP, and modulates Bax, AIF and endoplasmic reticulum stress proteins. Isoegomaketone also induces autophagy and keratinocyte proliferation, effectively reduces the levels of inflammatory factors and oxidative stress, inhibits adipocyte differentiation, and resensitizes TRAIL-resistant cancer cells. Isoegomaketone can be applied to research related to colorectal cancer, melanoma, lung cancer, prostate cancer, liver cancer, as well as rheumatoid arthritis and obesity[1][2][3][4].
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Isoegomaketone | Isoegomaketone is an orally active apoptosis inducer and radiosensitizer. Isoegomaketone regulates multiple key signaling pathways such as PI3K/AKT/mTOR, NF-κB, MAPK, cleaves Caspase family proteins and PARP, and modulates Bax, AIF and endoplasmic reticulum stress proteins. Isoegomaketone also induces autophagy and keratinocyte proliferation, effectively reduces the levels of inflammatory factors and oxidative stress, inhibits adipocyte differentiation, and resensitizes TRAIL-resistant cancer cells. Isoegomaketone can be applied to research related to colorectal cancer, melanoma, lung cancer, prostate cancer, liver cancer, as well as rheumatoid arthritis and obesity. | |||||||||||||||||||||
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- [1]. Wang R, et al. Advances in the Pharmacological Activities and Effects of Perilla Ketone and Isoegomaketone. Evid Based Complement Alternat Med. 2022;2022:8809792. Published 2022 Oct 28. [Content Brief]
- [2]. Cho BO, et al. Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells. Biosci Biotechnol Biochem. 2011;75(7):1306-1311. [Content Brief]
- [3]. Xu S, et al. Isoegomaketone improves radiotherapy efficacy and intestinal injury by regulating apoptosis, autophagy and PI3K/AKT/mTOR signaling in a colon cancer model. Oncol Rep. 2025;53(4):51. [Content Brief]
- [4]. Jin CH, et al. Isoegomaketone Alleviates the Development of Collagen Antibody-Induced Arthritis in Male Balb/c Mice. Molecules. 2017;22(7):1209. Published 2017 Jul 19. [Content Brief]
Keywords
