351353-48-5
351353-48-5
Chemical Structure
DPTIP
- CAS. Nr.: 351353-48-5
- Formula:C21H18N2O3S
- Molecular Weight:378.44
IUPAC Name: 2,6-dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol
InChIKey: JMXVHYPSBANVAQ-UHFFFAOYSA-N
SMILES: COC1=CC(C2=NC(C3=CC=CC=C3)=C(N2)C4=CC=CS4)=CC(OC)=C1O
Biological Activity: DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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DPTIP | 99.68% | DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM. | ||||||||||||||||||||
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References
- [1]. Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. [Content Brief]
- [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. [Content Brief]
