1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. DPTIP

DPTIP 

Cat. No.: HY-131002
Handling Instructions

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.

For research use only. We do not sell to patients.

DPTIP Chemical Structure

DPTIP Chemical Structure

CAS No. : 351353-48-5

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Description

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].

In Vitro

DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DPTIP potently (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1].
Dosage: 10 mg/kg.
Administration: IP 0.5 h prior to IL-1β striatal injection.
Result: Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4 h after compound administration.
The number of astrocyte-derived EVs was reduced by 51 ± 13% 2 h post IL-1β administration.
Molecular Weight

378.44

Formula

C₂₁H₁₈N₂O₃S

CAS No.

351353-48-5

SMILES

COC1=CC(C2=NC(C3=CC=CC=C3)=C(N2)C4=CC=CS4)=CC(OC)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DPTIPPhospholipaseexosomeN-SMaseextracellularvesiclesInhibitorinhibitorinhibit

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DPTIP
Cat. No.:
HY-131002
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