1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. DPTIP

DPTIP 

Cat. No.: HY-131002 Purity: 99.42%
COA Handling Instructions

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.

For research use only. We do not sell to patients.

DPTIP Chemical Structure

DPTIP Chemical Structure

CAS No. : 351353-48-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 132 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 620 In-stock
Estimated Time of Arrival: December 31
100 mg USD 980 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].

In Vitro

DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DPTIP potently (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1].
Dosage: 10 mg/kg.
Administration: IP 0.5 h prior to IL-1β striatal injection.
Result: Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4 h after compound administration.
The number of astrocyte-derived EVs was reduced by 51 ± 13% 2 h post IL-1β administration.
Molecular Weight

378.44

Formula

C21H18N2O3S

CAS No.
SMILES

COC1=CC(C2=NC(C3=CC=CC=C3)=C(N2)C4=CC=CS4)=CC(OC)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (660.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6424 mL 13.2121 mL 26.4243 mL
5 mM 0.5285 mL 2.6424 mL 5.2849 mL
10 mM 0.2642 mL 1.3212 mL 2.6424 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DPTIP
Cat. No.:
HY-131002
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