35604-67-2
Chemical Structure
Viloxazine hydrochloride
Synonym(s): Viloxazin hydrochloride; Emovit hydrochloride
- CAS No.: 35604-67-2
- Formula:C13H20ClNO3
- Molecular Weight:273.76
IUPAC Name: 2-((2-ethoxyphenoxy)methyl)morpholine hydrochloride
InChIKey: HJOCKFVCMLCPTP-UHFFFAOYSA-N
SMILES: CCOC1=C(OCC2OCCNC2)C=CC=C1.Cl
Biological Activity: Viloxazine hydrochloride is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50=0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50=32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD)[1][2][3].
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Viloxazine hydrochloride | 98.94% | Viloxazine hydrochloride is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50=0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50=32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD). | ||||||||||||||||||||
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(rac)-Viloxazine-d5 hydrochloride | (rac)-Viloxazine-d5 (hydrochloride) is the deuterium labeled (rac)-Viloxazine hydrochloride. | |||||||||||||||||||||
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- [1]. Yu C, et al. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300. [Content Brief]
- [2]. Garcia-Olivares J, et al. Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder. J Exp Pharmacol. 2024 Jan 16;16:13-24. [Content Brief]
- [3]. Findling RL, et al. Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status. CNS Drugs. 2021 Jun;35(6):643-653. [Content Brief]
