35604-67-2
35604-67-2
Chemical Structure
Viloxazine hydrochloride
Synonym(s): Viloxazin hydrochloride; Emovit hydrochloride
- CAS No.: 35604-67-2
- Formula:C13H20ClNO3
- Molecular Weight:273.76
IUPAC Name: 2-((2-ethoxyphenoxy)methyl)morpholine hydrochloride
InChIKey: HJOCKFVCMLCPTP-UHFFFAOYSA-N
SMILES: CCOC1=C(OCC2OCCNC2)C=CC=C1.Cl
Biological Activity: Viloxazine hydrochloride is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50=0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50=32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Viloxazine hydrochloride | 98.94% | Viloxazine hydrochloride is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50=0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50=32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD). | ||||||||||||||||||||
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(rac)-Viloxazine-d5 hydrochloride | (rac)-Viloxazine-d5 (hydrochloride) is the deuterium labeled (rac)-Viloxazine hydrochloride. | |||||||||||||||||||||
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Bufetolol | Bufetolol is an inhibitor for β-adrenergic receptor, that affects the maximum velocity of rise of the action potential, and exhibits antiarrhythmic efficacy. | |||||||||||||||||||||
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Ranolazine impurity 8 | Ranolazine impurity 8 is an impurity of Ranolazine. | |||||||||||||||||||||
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(R)-Viloxazine hydrochloride | 99.08% | (R)-Viloxazine hydrochloride is the less active R-isomer of Viloxazine hydrochloride (HY-125784). (R)-Viloxazine hydrochloride can be used in the research of depression. | ||||||||||||||||||||
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(R)-Viloxazine-d5 hydrochloride | (R)-Viloxazine-d5 hydrochloride ((R)-Viloxazin-d5 hydrochloride; (R)-Emovit-d5 hydrochloride) is the deuterated-labeled (R)-Viloxazine hydrochloride (HY-125784A). (R)-Viloxazine hydrochloride is the less active R-isomer of Viloxazine hydrochloride (HY-125784). (R)-Viloxazine hydrochloride can be used in the research of depression. | |||||||||||||||||||||
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(S)-Viloxazine hydrochloride | 99.90% | (S)-Viloxazine hydrochloride is the isomer of Viloxazine hydrochloride (HY-125784). Viloxazine hydrochloride is the hydrochloride salt form of Viloxazine (HY-W380450). Viloxazine (Viloxazin) hydrochloride is a norepinephrine reuptake inhibitor and a potent 5-HT2C agonist agent and 5-HT2B antagonist，EC50 for 5-HT2C b> is 32 μM，and the IC50 for 5-HT2B is 27 μM. Viloxazine hydrochloride's mechanism of action primarily involves serotonergic and noradrenergic pathways. Viloxazine hydrochloride is used in antidepressant research. | ||||||||||||||||||||
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(S)-Viloxazine-d5 hydrochloride | 98.19% | (S)-Viloxazine-d5 (hydrochloride) is the deuterium labeled (S)-Viloxazine hydrochloride. | ||||||||||||||||||||
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Mephenoxalone (Standard) | ≥98% | Mephenoxalone (Standard) is the analytical standard of Mephenoxalone. This product is intended for research and analytical applications. Mephenoxalone is a muscle relaxant with anti-anxiety activity. Mephenoxalone has neuropharmacologic activity in vivo. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc. | ||||||||||||||||||||
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Indeloxazine hydrochloride | Indeloxazine hydrochloride is a 5-HT receptor and norepinephrine (NE) reuptake inhibitor. Indeloxazine hydrochloride is an antidepressant and cerebral activator. | |||||||||||||||||||||
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Viloxazine (Standard) | ≥98% | Viloxazine is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50= 0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50= 32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD). | ||||||||||||||||||||
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References
- [1]. Yu C, et al. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300. [Content Brief]
- [2]. Garcia-Olivares J, et al. Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder. J Exp Pharmacol. 2024 Jan 16;16:13-24. [Content Brief]
- [3]. Findling RL, et al. Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status. CNS Drugs. 2021 Jun;35(6):643-653. [Content Brief]
