357649-93-5
357649-93-5
Chemical Structure
CPTH2
- CAS No.: 357649-93-5
- Formula:C14H14ClN3S
- Molecular Weight:291.80
IUPAC Name: 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole
InChIKey: YYTHPXHGWSAKIZ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1
Biological Activity: CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CPTH2 | 99.67% | CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B). | ||||||||||||||||||||
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CPTH2-d4 | CPTH2-d4 is the deuterated-labeled CPTH2 (HY-W013274). CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B). | |||||||||||||||||||||
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References
- [1]. Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. [Content Brief]
- [2]. Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6. [Content Brief]
