362003-83-6
362003-83-6
Chemical Structure
NVP 231
- CAS No.: 362003-83-6
- Formula:C25H25N3O2S
- Molecular Weight:431.55
IUPAC Name: (3r,5r,7r)-N-(2-benzamidobenzo[d]thiazol-6-yl)adamantane-1-carboxamide
InChIKey: MVSSJPGNLQPWSW-ZMQFCWPISA-N
SMILES: O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC4=CC=C5N=C(NC(C6=CC=CC=C6)=O)SC5=C4
Biological Activity: NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK[1]. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage[2].
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NVP 231 | 99.73% | NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage. | ||||||||||||||||||||
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References
- [1]. Graf C, et al. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32. [Content Brief]
- [2]. Graf C, et al. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal Biochem. 2009 Jan 1;384(1):166-9. [Content Brief]
Keywords
