36284-77-2
Chemical Structure
Hederasaponin B
- CAS No.: 36284-77-2
- Formula:C59H96O25
- Molecular Weight:1205.38
IUPAC Name: (2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
InChIKey: NVSLBOBPSCMMSO-BVLVEXITSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](O[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@]([H])(O[C@@H]3C(C)(C)[C@@](CC[C@]4(C)[C@@]5(CC=C6[C@]4(CC[C@]7(C(O[C@@H]8O[C@H](CO[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@]%10([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%10)[C@@H](CO)O9)[C@@H](O)[C@H](O)[C@H]8O)=O)[C@@]6([H])CC(C)(C)CC7)C)[H])([H])[C@]5(C)CC3)OC1
Biological Activity: Hederasaponin B is an orally active oleanane-type triterpenoid saponin and antiviral agent. Hederasaponin B is isolated from the leaves of Acanthopanax senticosus, Hedera nepalensis var. sinensis, and the rhizomes of Souliea vaginata. Hederasaponin B inhibits the expression of the viral capsid protein VP2 and attenuates virus-induced cytopathic effects. Hederasaponin B exhibits activity against Enterovirus 71 subtypes C3 and C4a. Hederasaponin B shows no hepatoprotective effect against CCl4-induced hepatocyte injury. Hederasaponin B is used in research on hand, foot, and mouth disease[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Hederasaponin B | 99.56% | Hederasaponin B is an orally active oleanane-type triterpenoid saponin and antiviral agent. Hederasaponin B is isolated from the leaves of Acanthopanax senticosus, Hedera nepalensis var. sinensis, and the rhizomes of Souliea vaginata. Hederasaponin B inhibits the expression of the viral capsid protein VP2 and attenuates virus-induced cytopathic effects. Hederasaponin B exhibits activity against Enterovirus 71 subtypes C3 and C4a. Hederasaponin B shows no hepatoprotective effect against CCl4-induced hepatocyte injury. Hederasaponin B is used in research on hand, foot, and mouth disease. | ||||||||||||||||||||
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Hederasaponin B (Standard) | ≥98% | Hederasaponin B (Standard) is the analytical standard of Hederasaponin B. This product is intended for research and analytical applications. Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71). | ||||||||||||||||||||
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References
- [1]. Song J, et al. Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a. Biomolecules & therapeutics. 2014 Jan;22(1):41-6. [Content Brief]
- [2]. Wua H, et al. A New Cytotoxic Cyclolanostane Triterpenoid Xyloside from Souliea vaginata. Natural product communications. 2017 Feb;12(2):229-232. [Content Brief]
- [3]. Li CX, et al. Structural characterization of the metabolites of orally ingested hederasaponin B, a natural saponin that is isolated from Acanthopanax senticosus leaves by liquid chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 Apr 15;197:113929.
