373370-73-1
Chemical Structure
MitoBloCK-1
Synonym(s): MB-1
- CAS No.: 373370-73-1
- Formula:C14H14BrN3O2S
- Molecular Weight:368.25
IUPAC Name: (E)-2-((3-bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene)hydrazine-1-carbothioamide
InChIKey: VBDLLTJWFFBEAG-UBKPWBPPSA-N
SMILES: S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N
Biological Activity: MitoBloCK-1 (MB-1) is a TIM22 inhibitor. MitoBloCK-1 inhibits substrate translocation by preventing substrate binding to the tim9/10 complex, thereby preventing substrates from reaching the TIM22 translocase. MitoBloCK-1 inhibits the import of TIM22 substrate proteins into mitochondria. MitoBloCK-1 can be used in research on cardiac arrhythmia and P. aeruginosa infection[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MitoBloCK-1 | 98.87% | MitoBloCK-1 (MB-1) is a TIM22 inhibitor. MitoBloCK-1 inhibits substrate translocation by preventing substrate binding to the tim9/10 complex, thereby preventing substrates from reaching the TIM22 translocase. MitoBloCK-1 inhibits the import of TIM22 substrate proteins into mitochondria. MitoBloCK-1 can be used in research on cardiac arrhythmia and P. aeruginosa infection. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Bhoknal MR, et al. 3D-QSAR and Molecular Docking Studies of Antiarrhythmic Activity of Cardiac Sodium Channel (PDB: 8F6P) with Simulation Dynamic on a Series of Phenytoin Derivatives. Asian Journal of Biological and Life Sciences. 2026 May;15(2):429-40.
- [2]. Tomaras AP, et al. Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy. 2013 Sep;57(9):4197-207.
- [3]. Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proceedings of the National Academy of Sciences of the United States of America. 2010 May 25;107(21):9578-83. [Content Brief]
- [4]. Ding YY, et al. Design, Synthesis, and Antimicrobial Activity Evaluation of Novel Isocryptolepine Derivatives against Phytopathogenic Fungi and Bacteria. Journal of agricultural and food chemistry. 2024 Sep 25;72(38):20831-20841. [Content Brief]
