373370-73-1
Chemical Structure
MitoBloCK-1
Synonym(s): MB-1
- CAS No.: 373370-73-1
- Formula:C14H14BrN3O2S
- Molecular Weight:368.25
IUPAC Name: (E)-2-((3-bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene)hydrazine-1-carbothioamide
InChIKey: VBDLLTJWFFBEAG-UBKPWBPPSA-N
SMILES: S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N
Biological Activity: MitoBloCK-1 (MB-1) is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MitoBloCK-1 | 98.87% | MitoBloCK-1 (MB-1) is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40. | ||||||||||||||||||||
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References
- [1]. Wijaya J. Utilizing Small Molecules to Study Mitochondrial Presequence-Degrading Protease. UCLA, 2015.
- [2]. Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9578-83. [Content Brief]
