388086-13-3
388086-13-3
Chemical Structure
SIRT1/2/3-IN-2
- CAS No.: 388086-13-3
- Formula:C21H14Cl2N2O2
- Molecular Weight:397.25
IUPAC Name: N-(2-(2,4-dichlorophenyl)benzo[d]oxazol-5-yl)-2-phenylacetamide
InChIKey: HUGVXMJZAPFVHU-UHFFFAOYSA-N
SMILES: ClC1=C(C2=NC3=CC(NC(CC4=CC=CC=C4)=O)=CC=C3O2)C=CC(Cl)=C1
Biological Activity: SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 μM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma[1].
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SIRT1/2/3-IN-2 | SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 μM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma. | |||||||||||||||||||||
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