388575-52-8
388575-52-8
Chemical Structure
PSN 375963
- CAS No.: 388575-52-8
- Formula:C17H23N3O
- Molecular Weight:285.38
IUPAC Name: 5-(4-butylcyclohexyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole
InChIKey: OAVLEYPTWABFLF-UHFFFAOYSA-N
SMILES: CCCCC1CCC(C2=NC(C3=CC=NC=C3)=NO2)CC1
Biological Activity: PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PSN 375963 | 99.95% | PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
PSN 375963 (Standard) | PSN 375963 (Standard) is the analytical standard of PSN 375963 (HY-108258). This product is intended for research and analytical applications. PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. [Content Brief]
- [2]. Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065. [Content Brief]
Keywords
