39791-20-3
39791-20-3
Chemical Structure
Nilestriol
Synonym(s): Nylestriol; EE3CPE
- CAS No.: 39791-20-3
- Formula:C25H32O3
- Molecular Weight:380.52
IUPAC Name: (8R,9S,13S,14S,16R,17R)-3-(cyclopentyloxy)-17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
InChIKey: CHZJRGNDJLJLAW-RIQJQHKOSA-N
SMILES: C#C[C@]1(O)[C@H](O)C[C@@]2([H])[C@]3([H])CCC4=C(C=CC(OC5CCCC5)=C4)[C@@]3([H])CC[C@]12C
Biological Activity: Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nilestriol | 98.93% | Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women. | ||||||||||||||||||||
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Ethynyl estradiol 3-sulfate | Ethynyl estradiol 3-sulfate (17α-Ethynylestradiol-3-sulfate; EE-3-SO4) can prolong the median survival time of rats in an acute severe blood loss model by approximately 6 times, with a 6-hour survival rate of 80%. | |||||||||||||||||||||
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Ethinylestradiol | 99.96% | Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers. | ||||||||||||||||||||
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Ethynyl Estradiol-13C2 | 98.64% | Ethynyl Estradiol-13C2 is the 13C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Mestranol | 99.69% | Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders. Mestranol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Estradiol acetate | Estradiol acetate is a novel orally active Estradiol (HY-B0141) prodrug. Estradiol acetate reduces the frequency and severity of postmenopause symptoms. Estradiol acetate can be used in the research of menopausal symptoms. | |||||||||||||||||||||
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Quinestrol | 99.19% | Quinestrol (W-3566) is an orally effective synthetic estrogen compound that acts on CYP3A4, CYP1A2, and GnRH. Quinestrol interferes with GnRH release and disrupts the hypothalamic-pituitary-ovarian axis. Quinestrol downregulates the gene expression of follicle-stimulating hormone β and luteinizing hormone β, induces oxidative stress, damages reproductive organs, reduces sperm density and motility, increases sperm malformation rate, and alters the levels of sex hormones such as testosterone, luteinizing hormone, estradiol, and progesterone. Quinestrol can be used in studies related to reproductive function regulation. | ||||||||||||||||||||
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Estradiol 3-methyl ether | 99.07% | Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer. | ||||||||||||||||||||
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Estradiol Valerate impurity 6 | Estradiol Valerate impurity 6 is an impurity of Estradiol Valerate. | |||||||||||||||||||||
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Estriol impurity 2 | Estriol impurity 2 (3-Methoxyestriol) is an impurity of Estriol. | |||||||||||||||||||||
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Ethinylestradiol impurity 3 | Ethinylestradiol impurity 3 (17beta-Ethinylestradiol) is an impurity of Ethinylestradiol. | |||||||||||||||||||||
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