39832-48-9
39832-48-9
Chemical Structure
Tazolol
- CAS No.: 39832-48-9
- Formula:C9H16N2O2S
- Molecular Weight:216.30
InChIKey: DREVJBVJBRSSDL-UHFFFAOYSA-N
SMILES: OC(CNC(C)C)COC1=NC=CS1
Biological Activity: Tazolol is a specific β-adrenergic antagonist (IC50: 700 nM for (-) isoproterenol-elicited accumulation of cyclic AMP in rat cortical slices). Tazolol produces a significant and sustained increase in cardiac output and stroke volume. Tazolol can be used in the research of heart failure[1][2].
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Tazolol | Tazolol is a specific β-adrenergic antagonist (IC50: 700 nM for (-) isoproterenol-elicited accumulation of cyclic AMP in rat cortical slices). Tazolol produces a significant and sustained increase in cardiac output and stroke volume. Tazolol can be used in the research of heart failure. | |||||||||||||||||||||
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References
- [1]. Skolnick, et al. Blockade of central beta-adrenergic receptors by tazolol (1-isopropylamino-3-(2-thiazoloxy)-2-propanol). Life Sci. 1977 Dec 1;21(11):1655-63. [Content Brief]
- [2]. Buckley HT, et al. Circulatory effects of tazolol in experimental myocardial infarction. Am J Cardiol. 1975 May;35(5):619-25. [Content Brief]
Keywords
