425671-29-0
425671-29-0
Chemical Structure
LY518674
Synonym(s): LY-674
- CAS No.: 425671-29-0
- Formula:C23H27N3O4
- Molecular Weight:409.48
IUPAC Name: 2-methyl-2-(4-(3-(1-(4-methylbenzyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)propanoic acid
InChIKey: PNHFDVSKDSLUFH-UHFFFAOYSA-N
SMILES: CC(C)(OC1=CC=C(CCCC2=NC(N(CC3=CC=C(C)C=C3)N2)=O)C=C1)C(O)=O
Biological Activity: LY518674 is a potent, selective PPARα agonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3].
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LY518674 | 98.50% | LY518674 is a potent, selective PPARα agonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis. | ||||||||||||||||||||
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References
- [1]. Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. [Content Brief]
- [2]. Nissen SE, et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA. 2007 Mar 28;297(12):1362-73. [Content Brief]
- [3]. Khera AV, et al. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2. [Content Brief]
Keywords
