1. Cell Cycle/DNA Damage
  2. PPAR
  3. LY518674

LY518674 (Synonyms: LY-674)

Cat. No.: HY-50665
Handling Instructions

LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis.

For research use only. We do not sell to patients.

LY518674 Chemical Structure

LY518674 Chemical Structure

CAS No. : 425671-29-0

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Description

LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3].

IC50 & Target

EC50: 42 nM (human PPARα)[1]

In Vivo

LY518674 reduces triglycerides and increased HDL-C in vivo[2].
LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3].

Clinical Trial
Molecular Weight

409.48

Formula

C₂₃H₂₇N₃O₄

CAS No.

425671-29-0

SMILES

CC(C)(OC1=CC=C(CCCC2=NC(N(CC3=CC=C(C)C=C3)N2)=O)C=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LY518674LY-674LY 518674LY-518674LY674LY 674PPARPeroxisome proliferator-activated receptorsPPARαatherosclerosisInhibitorinhibitorinhibit

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LY518674
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