442644-28-2
Chemical Structure
JW67
- CAS No.: 442644-28-2
- Formula:C21H18N2O6
- Molecular Weight:394.38
IUPAC Name: trispiro[indoline-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indoline]-2,2'''-dione
InChIKey: BTXRSHKJNDFHGA-UHFFFAOYSA-N
SMILES: O=C1C2(OCC3(COC4(C5=CC=CC=C5NC4=O)OC3)CO2)C6=CC=CC=C6N1
Biological Activity: JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JW67 | 98.15% | JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
JW67 (Standard) | ≥98% | JW67 (Standard) is the analytical standard of JW67 (HY-108442). This product is intended for research and analytical applications. JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
