448895-37-2
448895-37-2
Chemical Structure
NS1643
- CAS No.: 448895-37-2
- Formula:C15H10F6N2O3
- Molecular Weight:380.24
IUPAC Name: 1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea
InChIKey: NJFVQMRYJZHGME-UHFFFAOYSA-N
SMILES: O=C(NC1=C(O)C=CC(C(F)(F)F)=C1)NC2=C(O)C=CC(C(F)(F)F)=C2
Biological Activity: NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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NS1643 | 99.04% | NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-12151NS 1738 -
Similarity Score 0.63
HY-I0673Flucofuron -
Similarity Score 0.62
HY-105661RIMD-0560 (Standard) -
Similarity Score 0.62
HY-152094SRD5A1-IN-1 -
Similarity Score 0.61
![1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea Chemical Structure](//file.medchemexpress.com/product_pic/hy-w046841.gif)
HY-W0468411,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea -
Similarity Score 0.60
HY-10172IMD-0354 -
Similarity Score 0.59
HY-I0677Regorafenib impurity 8 -
Similarity Score 0.58
HY-147003MMV687807 -
Similarity Score 0.58
HY-144761TOPK-p38/JNK-IN-1 -
Explore the MedChemAI to find more analogs
![1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w046841.gif)
References
- [1]. Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11. [Content Brief]
- [2]. Breuer EK, et al. Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling. Cell Death Dis. 2019 Feb 21;10(3):180. [Content Brief]
