448895-37-2
448895-37-2
Chemical Structure
NS1643
- CAS No.: 448895-37-2
- Formula:C15H10F6N2O3
- Molecular Weight:380.24
IUPAC Name: 1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea
InChIKey: NJFVQMRYJZHGME-UHFFFAOYSA-N
SMILES: O=C(NC1=C(O)C=CC(C(F)(F)F)=C1)NC2=C(O)C=CC(C(F)(F)F)=C2
Biological Activity: NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NS1643 | 99.04% | NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells. | ||||||||||||||||||||
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References
- [1]. Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11. [Content Brief]
- [2]. Breuer EK, et al. Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling. Cell Death Dis. 2019 Feb 21;10(3):180. [Content Brief]
Keywords
