Flucofuron
Based on 1 Customer Validation
Flucofuron exhibits high efficacy against trophozoites of both N. fowleri strains (ATCC 30808 : IC50 = 2.58 μM and ATCC 30215: IC50 = 2.47 μM), being even active against the resistant cyst stage (IC50 = 0.88 μM). Flucofuron can induce cell apoptosis. Flucofuron can be used for the researches of infection and inflammation, such as Primary amoebic meningoencephalitis (PAM).
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 370-50-3
- Formula: C15H8Cl2F6N2O
- Molecular Weight:417.13
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Cell Death Library
HY-L162
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Anti-Drug-Resistant Compound Library
HY-L169
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
2.69 μM
Compound: SC78
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Cytotoxicity against human HeLa cells by SRB assay
Cytotoxicity against human HeLa cells by SRB assay
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[PMID: 36067930] |
| HepG2 | IC50 |
7.72 μM
Compound: SC78
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Cytotoxicity against human HepG2 cells by SRB assay
Cytotoxicity against human HepG2 cells by SRB assay
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[PMID: 36067930] |
| LAD2 | IC50 |
0.79 μM
Compound: DPU-7
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Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced beta-hexosaminidase release
Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced beta-hexosaminidase release
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[PMID: 35876064] |
Chemical Information
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CAS No. 370-50-3
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Appearance Solid
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Molecular Weight 417.13
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Formula C15H8Cl2F6N2O
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Color White to light yellow
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SMILES
O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)NC2=CC=C(Cl)C(C(F)(F)F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (239.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3973 mL | 11.9867 mL | 23.9733 mL | 59.9334 mL |
| 5 mM | 0.4795 mL | 2.3973 mL | 4.7947 mL | 11.9867 mL | |
| 10 mM | 0.2397 mL | 1.1987 mL | 2.3973 mL | 5.9933 mL | |
| 15 mM | 0.1598 mL | 0.7991 mL | 1.5982 mL | 3.9956 mL | |
| 20 mM | 0.1199 mL | 0.5993 mL | 1.1987 mL | 2.9967 mL | |
| 25 mM | 0.0959 mL | 0.4795 mL | 0.9589 mL | 2.3973 mL | |
| 30 mM | 0.0799 mL | 0.3996 mL | 0.7991 mL | 1.9978 mL | |
| 40 mM | 0.0599 mL | 0.2997 mL | 0.5993 mL | 1.4983 mL | |
| 50 mM | 0.0479 mL | 0.2397 mL | 0.4795 mL | 1.1987 mL | |
| 60 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9989 mL | |
| 80 mM | 0.0300 mL | 0.1498 mL | 0.2997 mL | 0.7492 mL | |
| 100 mM | 0.0240 mL | 0.1199 mL | 0.2397 mL | 0.5993 mL |
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