474-86-2
474-86-2
Chemical Structure
Equilin
Synonym(s): 7-Dehydroestrone
- CAS. Nr.: 474-86-2
- Formula:C18H20O2
- Molecular Weight:268.35
IUPAC Name: (9S,13S,14S)-3-hydroxy-13-methyl-6,9,11,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one
InChIKey: WKRLQDKEXYKHJB-HFTRVMKXSA-N
SMILES: C[C@]1([C@](CC2)([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O
Biological Activity: Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Equilin | 99.79% | Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. | ||||||||||||||||||||
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Equilin (Standard) | ≥98% | Equilin (Standard) is the analytical standard of Equilin. This product is intended for research and analytical applications. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. | ||||||||||||||||||||
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Equilin-d4 | Equilin-d4 is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. | |||||||||||||||||||||
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Equilin-d2 | Equilin-d2 (7-Dehydroestrone-d2) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. | |||||||||||||||||||||
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Conjugated estrogen sodium | Conjugated estrogen sodium is a medication composed of a blend of estrogen hormones, utilized in the treatment of moderate to severe hot flashes, vaginal changes, and various other symptoms associated with menopause or decreased estrogen levels. | |||||||||||||||||||||
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2-Hydroxyestrone | 98.15% | 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic. | ||||||||||||||||||||
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16α-Hydroxyestrone (Standard) | ≥98% | 16α-Hydroxyestrone (Standard) is the analytical standard of 16α-Hydroxyestrone. This product is intended for research and analytical applications. 16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease. | ||||||||||||||||||||
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Equilenin | 95.0% | Equilenin is a B-ring unsaturated estrogen discovered in pregnant mare urine and is one of the major components of Premarin, a drug commonly used for estrogen replacement therapy. Equilenin binds to estrogen receptors in the body and exerts effects similar to endogenous estrogens. Equilenin weakly binds to and activates the aryl hydrocarbon receptor (AhR) to induce CYP1A1 expression. Equilenin exhibits high affinity for sex hormone-binding globulin (SHBG/SBP) and is metabolized by CYP1A1/1B1 to 4-hydroxy and 17β-dihydro derivatives. Equilenin is used in breast cancer-related research. | ||||||||||||||||||||
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β-Dihydroequilin-d3 | β-Dihydroequilin-d3 is the deuterium labeled β-Dihydroequilin. | |||||||||||||||||||||
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Estrone | 99.96% | Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells. | ||||||||||||||||||||
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Estrone-13C3 | 98.0% | Estrone-13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells. | ||||||||||||||||||||
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Estrone-13C2 | Estrone-13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells. | |||||||||||||||||||||
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Estrone-d2-1 | Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells. | |||||||||||||||||||||
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References
- [1]. David K, et al. Some biological properties of equilin. Biochem J. 1935;29(2):371-377. [Content Brief]
- [2]. Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147(2):211-220. [Content Brief]
