4776-06-1
4776-06-1
Chemical Structure
Fluorosalan
- CAS No.: 4776-06-1
- Formula:C14H8Br2F3NO2
- Molecular Weight:439.03
IUPAC Name: 3,5-dibromo-2-hydroxy-N-(3-(trifluoromethyl)phenyl)benzamide
InChIKey: VYKKDKFTDMVOBU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(=C1)C(F)(F)F)C=2C=C(Br)C=C(Br)C2O
Biological Activity: Fluorosalan is an NF-κB inhibitor. Fluorosalan blocks the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα. Fluorosalan induces depolarization of mitochondrial membrane potential in cancer cells and inhibits the growth of various cancer cells. Fluorosalan can be used in studies related to cervical cancer and rheumatoid arthritis[1][2].
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Fluorosalan | Fluorosalan is an NF-κB inhibitor. Fluorosalan blocks the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα. Fluorosalan induces depolarization of mitochondrial membrane potential in cancer cells and inhibits the growth of various cancer cells. Fluorosalan can be used in studies related to cervical cancer and rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Miller SC, et al. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical pharmacology. 2010 May 01;79(9):1272-80. [Content Brief]
- [2]. Chakraborty D, et al. Potential role of Bavachin in Rheumatoid arthritis: Informatics approach for rational based selection of phytoestrogen[J]. Journal of Herbal Medicine, 2023, 38: 100640.
