480-64-8
480-64-8
Chemical Structure
Orsellinic acid
- CAS No.: 480-64-8
- Formula:C8H8O4
- Molecular Weight:168.15
IUPAC Name: 2,4-dihydroxy-6-methylbenzoic acid
InChIKey: AMKYESDOVDKZKV-UHFFFAOYSA-N
SMILES: OC(C1=C(C=C(O)C=C1O)C)=O
Biological Activity: Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer)[1][2][3].
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Orsellinic acid | 98.36% | Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer). | ||||||||||||||||||||
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Orsellinic acid (Standard) | ≥98% | Orsellinic acid (Standard) is an analytical standard of Orsellinic acid (HY-N3126). This product is intended for research and analytical applications. Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer). | ||||||||||||||||||||
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References
- [1]. Lopes TI, et al. Radical-scavenging activity of orsellinates. Chem Pharm Bull (Tokyo). 2008;56(11):1551-1554. [Content Brief]
- [2]. Bashyal BP, et al. Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum. J Nat Prod. 2005 May;68(5):724-8. [Content Brief]
- [3]. Ryan SD, et al. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J Neurochem. 2007 Oct;103(1):88-97. [Content Brief]
