480-79-5
480-79-5
Chemical Structure
(-)-Integerrimine
- CAS No.: 480-79-5
- Formula:C18H25NO5
- Molecular Weight:335.39
IUPAC Name: (5R,6R,9a1R,14aR,E)-3-ethylidene-6-hydroxy-5,6-dimethyl-3,4,5,6,9,9a1,11,13,14,14a-decahydro-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
InChIKey: HKODIGSRFALUTA-IKZAEVNJSA-N
SMILES: O=C1O[C@@]2([H])[C@]3([H])N(CC=C3COC([C@](O)([C@@H](C/C1=C\C)C)C)=O)CC2
Biological Activity: (-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].
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(-)-Integerrimine | (-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila. | |||||||||||||||||||||
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References
- [1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7. [Content Brief]
- [2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25. [Content Brief]
Keywords
