482-74-6
Chemical Structure
Cryptopine
- CAS No.: 482-74-6
- Formula:C21H23NO5
- Molecular Weight:369.41
IUPAC Name: 11,12-dimethoxy-7-methyl-6,8,9,15-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c]benzo[g]azecin-14(7H)-one
InChIKey: XPOJSWHIKCNLEQ-UHFFFAOYSA-N
SMILES: CN(CC1=C(C=CC2=C1OCO2)C3)CCC4=C(C3=O)C=C(OC)C(OC)=C4
Biological Activity: Cryptopine is a non-narcotic isoquinoline alkaloid. Cryptopine can reduce the activities of glutathione S-transferase (GST) and glutathione reductase (GR), depletes intracellular glutathione levels, stimulates lipid peroxidation, and induces cytotoxicity by disrupting the cellular defense system. Cryptopine binds stably to key targets of liver cancer and also exhibits anthelmintic activity against Dactylogyrus intermedius. Cryptopine can be used in studies related to liver cancer and Dactylogyrus intermedius infection[1][2][3][4].
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Cryptopine | Cryptopine is a non-narcotic isoquinoline alkaloid. Cryptopine can reduce the activities of glutathione S-transferase (GST) and glutathione reductase (GR), depletes intracellular glutathione levels, stimulates lipid peroxidation, and induces cytotoxicity by disrupting the cellular defense system. Cryptopine binds stably to key targets of liver cancer and also exhibits anthelmintic activity against Dactylogyrus intermedius. Cryptopine can be used in studies related to liver cancer and Dactylogyrus intermedius infection. | |||||||||||||||||||||
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[1]. Batool S, et al. Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer. Pharmaceuticals (Basel). 2022 May 25;15(6):654.
[Content Brief] - [2]. Aneja R, et al. Stimulation of lipid peroxidation and impairment of glutathione-dependent defense system in Wistar rats treated with cryptopine, a rare non-narcotic opium alkaloid. European journal of drug metabolism and pharmacokinetics. 2004;29(1):31-6. [Content Brief]
- [3]. Vrancheva RZ, et al. Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2016;71(1-2):9-14. [Content Brief]
- [4]. Wang GX, et al. In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus. Veterinary parasitology. 2010 Aug 04;171(3-4):305-13. [Content Brief]
Keywords
