494-04-2
494-04-2
Chemical Structure
Nicotelline
Synonym(s): Nicotellin
- CAS No.: 494-04-2
- Formula:C15H11N3
- Molecular Weight:233.27
IUPAC Name: 3,2':4',3''-terpyridine
InChIKey: OILSPHJMIPYURT-UHFFFAOYSA-N
SMILES: C1(C2=CC=NC(C3=CN=CC=C3)=C2)=CN=CC=C1
Biological Activity: Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6). CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Nicotelline | 98.88% | Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6). CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Nicotelline-d9 | Nicotelline-d9 is the deuterium labeled Nicotelline. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Denton TT, et al. Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. Biochem Pharmacol. 2004 Feb 15;67(4):751-6. [Content Brief]
- [2]. Jacob P 3rd, et al. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18;26(11):1615-31. [Content Brief]
